A New Insight into Pathogenesis of Carbon Tetrachloride Fat Infiltration.

Abstract

Intravenous administration of Triton to rats causes a marked elevation of plasma triglycerides. If the rats have been poisoned with carbon tetrachloride 2 hours previously, accumulation of triglycerides in the plasma following Triton administration is markedly reduced. The existence of an hepatic triglyceride secretory mechanism is inferred from the work of others, and it is postulated that carbon tetrachloride poisons this triglyceride secretory mechanism. Triglycerides, which would normally be secreted into plasma, are retained in the liver.