The Journal of Antibiotics · 1992 · 47 citations · 13 references
PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryOrganic ChemistryStructure-activity RelationshipsMacrocycle SynthesisAntibiotic DiscoveryAntimicrobial MetabolitesBiological Activity FeaturesLactam MacrocyclesMacrolide AntibioticsStructural Elucidation From SpectraSubstituent Effects On Biological Activity
A Streptomyces strain labeled A14106 was isolated and found to produce a novel 20-membered macrocyclic lactam derivative, BE-14106, which exhibited both cytotoxic activity against murine tumor cell lines and antimicrobial activity.
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Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth
Donald E. Ingber, Takeshi Fujita, SHOJI KISHIMOTO et al. · Nature · 1990 · 1.3K citations
Medicine, Oncology, Pharmacology +14