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Human Basic Fibroblast Growth Factor: Nucleotide Sequence, Genomic Organization, and Expression in Mammalian Cells
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1986
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Endothelial CellsCell ProliferationBiomedical EngineeringCell GrowthNew Capillary GrowthNew SproutsAngiogenesisGenomic OrganizationFibroblast Growth FactorNucleotide SequenceCapillary NetworkHealth SciencesFibrosisVascular AdaptationMorphogenesisVascular BiologyNeovascularizationOrganogenesisMammalian CellsCell BiologyFibroblast BiologyDevelopmental BiologyMedicineExtracellular Matrix
Angiogenesis, the process of new capillary growth, involves a series of steps, including the proliferation and migration of vascular endothelial cells. At the on-set of angiogenesis, existing capillaries located close to the site of an angiogenic stimulus are induced to form new sprouts. These sprouts contain dividing endothelial cells, with migrating endothelial cells at the sprout tips. Eventually, the sprouts unite and form new capillary tubes (for review, see Folkman 1985).