Muramidase Activity in Leukemic Rats

Abstract

1. Greatly elevated serum and urine muramidase levels were observed in rats with transplanted chloroleukemia. 2. In one chloroleukemic rat with ascites, the fluid had a very high muramidase content. 3. Homogenates of chloroma cells consisting of myeloblasts and promyelocytes had very high muramidase activity. 4. In rats with acute mononuclear cell leukemia, no significant elevation of serum or urinary muramidase activity was noted, suggesting rat mononuclear leukemia is not myelogenous or monocytic in origin.