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Experimental Lathyrism in the Rat. Nature of Defect in Epiphysial Cartilage
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1958
Year
Tissue EngineeringCollagen FibrilsCollagen FibersAnatomyOrthopaedic SurgeryMusculoskeletal ResearchEpiphysial CartilageCartilage Matrix BiologyTropocollagen MoleculeCartilage DegenerationOsteoarthritisMatrix BiologyHealth SciencesConnective Tissue DiseaseExperimental LathyrismMusculoskeletal TissueDevelopmental BiologyPhysiologyWound HealingMedicineHuman TissueExtracellular Matrix
SummaryThe hydroxyproline, and hence collagen, content of epiphysial cartilage from rats treated with AAN is not reduced from the normal. Homogenized fractions of cartilage from rats which have received AAN are virtually devoid of collagen fibrils when examined with electron microscope. The defect appears to be a failure of the tropocollagen molecule to form collagen fibers.