Experimental Biology and Medicine · 1964 · 46 citations · 0 references
PharmacyToxicologyAquatic ToxicologyImmunotoxicologyMarine ToxicologyImmunotoxicity In Aquatic OrganismsNeurotoxicity In Marine OrganismsFormaldehydeHemagglutination AssaysHemagglutination Inhibition AssaysShellfish BiotoxinsShellfish ContaminationShellfish SafetyShellfish ToxicityShellfish Toxin Contamination
Paralytic shellfish poison, conjugated to protein by formaldehyde condensation, was shown to possess haptenic properties, as demonstrated by passive hemagglutination and mouse protection tests with anti-sera obtained from rabbits immunized to PSP-HCHO-BSA. The anti-PSP produced to PSP-HCHO-BSA was of low potency. Hap-tene inhibitions suggest, however, that the antisera may be satisfactory for sensitive and specific detection of PSP in contaminated shellfish and their marine environment.