Concepedia

Total Synthesis of Shishijimicin A

K. C. Nicolaou, Zhaoyong Lu, Ruofan Li, James R. Woods, Te-Ik Sohn

Journal of the American Chemical Society · 2015 · 52 citations · 29 references

DOI

Concepts

Abstract

The total synthesis of the rare but extremely potent antitumor agent shishijimicin A has been achieved via a convergent strategy involving carboline disaccharide 3 and hydroxy enediyne thioacetate 4.

References

29

p-Benzyne. Generation as an intermediate in a thermal isomerization reaction and trapping evidence for the 1,4-benzenediyl structure

Richard R. Jones, Robert G. Bergman · Journal of the American Chemical Society · 1972 · 669 citations

, , +5

Calichemicins, a novel family of antitumor antibiotics. 2. Chemistry and structure of calichemicin .gamma.1I

May D. Lee, T. S. DUNNE, Conway C. Chang et al. · Journal of the American Chemical Society · 1987 · 520 citations

, , +6

Mixed Mg/Li Amides of the Type R<sub>2</sub>NMgCl⋅LiCl as Highly Efficient Bases for the Regioselective Generation of Functionalized Aryl and Heteroaryl Magnesium Compounds

Arkady Krasovskiy, Valeria Krasovskaya, Paul Knochel · Angewandte Chemie International Edition · 2006 · 505 citations · Full text

, , +7

On the direct epoxidation of glycals: application of a reiterative strategy for the synthesis of .beta.-linked oligosaccharides

Randall L. Halcomb, Samuel J. Danishefsky · Journal of the American Chemical Society · 1989 · 455 citations

, , +9

Calichemicins, a novel family of antitumor antibiotics. 1. Chemistry and partial structure of calichemicin .gamma.1I

May D. Lee, T. S. DUNNE, Marshall M. Siegel et al. · Journal of the American Chemical Society · 1987 · 388 citations

, , +8