The presence of CXCR4⁺CD1a⁺cells at onset of Langerhans cell histiocytosis is associated with a less favorable outcome

Abstract

This study provides the first evidence that CXCR4 is involved in the homing and retention of LCH-cells in CXCL12-expressing tissues and qualifies CXCR4 as a candidate prognostic marker for less favorable disease outcome.