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A Comparison of Double-Isotope Derivative and Radioimmunological Estimation of Plasma Aldosterone Concentration in Man
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1973
Year
Plasma Aldosterone ConcentrationPlasma PoolAdrenal GlandBody CompositionBioanalysisBiostatisticsClinical ChemistryLaboratory MedicineHealth SciencesDouble-isotope DerivativeEndocrine MechanismAdrenal DiseaseEndocrinologyPharmacologyPotassium HomeostasisAldosterone PhysiologyPlasma DonationDouble-isotope Derivative MethodPhysiologyPrimary AldosteronismMetabolismMedicineNephrologyRadioimmunological Estimation
1. Two techniques for estimating plasma aldosterone concentration are compared by means of repeated assays of a plasma pool and also by analysis of a wide range of plasma samples. 2. No significant difference was found in the results obtained by the methods. Radioimmunoassay required only one tenth of the volume of plasma needed for the double-isotope derivative method. 3. Its rapidity and relative inexpensiveness makes radioimmunoassay at present the most suitable technique for large-scale population screening.