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Prediction of the precipitation profiles of weak base drugs in the small intestine using a simplified transfer (“dumping”) model coupled with in silico modeling and simulation approach

Pharmacokinetic ModelingSmall IntestineEnvironmental EngineeringMedicineWeak Base DrugsDrug AbsorptionPharmacologyPhysiologically-based Pharmacokinetic ModelingPharmacokineticsPharmacodynamic ModelingPrecipitation Profiles