Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

Monica Bucciantini, Elisa Giannoni, Fabrizio Chiti et al. · Nature · 2002 · 2.4K citations

Aggregates Implies, Protein Function, Biochemistry +14

World Alzheimer Report 2015.The Global Impact of Dementia: An analysis of prevalence, incidence, cost and trends.

Martin Prince, Anders Wimo, Maëlenn Guerchet et al. · HAL (Le Centre pour la Communication Scientifique Directe) · 2015 · 2.3K citations · Full text

Aging, Global Impact, Epidemiology Of Aging +16

An Analytical Solution to the Kinetics of Breakable Filament Assembly

Tuomas P. J. Knowles, Christopher A. Waudby, Glyn L. Devlin et al. · Science · 2009 · 1.1K citations

Biophysical Modeling, Engineering, Mechanical Engineering +22

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

Melanie Meyer‐Luehmann, Tara L. Spires‐Jones, Claudia Prada et al. · Nature · 2008 · 986 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Amyloid-β Plaques +8

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

Summer L. Bernstein, Nicholas Dupuis, Noel D. Lazo et al. · Nature Chemistry · 2009 · 905 citations · Full text

Neurodegenerative Diseases, Alzheimer's Disease, Biochemistry +8