Human proximal tubule epithelial cells cultured on hollow fibers: living membranes that actively transport organic cations

HK-2: An immortalized proximal tubule epithelial cell line from normal adult human kidney

Michael J. Ryan, Gretchen Johnson, J. M. W. KIRK et al. · Kidney International · 1994 · 880 citations

Urology, Renal Function, Medicine +11

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Kyung‐Jin Jang, Ali Poyan Mehr, Geraldine A. Hamilton et al. · Integrative Biology · 2013 · 814 citations

Tissue Engineering, Engineering, Cell Culture +22

Cisplatin Nephrotoxicity Is Critically Mediated via the Human Organic Cation Transporter 2

Giuliano Ciarimboli, Thomas Ludwig, Detlef Lang et al. · American Journal Of Pathology · 2005 · 443 citations

Molecular Pharmacology, Molecular Physiology, Biochemistry +5

Metformin is a Superior Substrate for Renal Organic Cation Transporter OCT2 rather than Hepatic OCT1

Naoko Kimura, Satohiro Masuda, Yuko Tanihara et al. · Drug Metabolism and Pharmacokinetics · 2005 · 356 citations

Replacement of renal function in uremic animals with a tissue-engineered kidney

H. David Humes, Deborah A. Buffington, Sherrill M. MacKay et al. · Nature Biotechnology · 1999 · 306 citations

Regenerative Medicine, Glomerulonephritis, Urology +12