Applied Organometallic Chemistry · 2012 · 14 citations · 29 references
Natural SciencesChemistryMedicinal ChemistryOrganic ChemistryOrganometallic ChemistryStructure-activity RelationshipsEnzyme InhibitionLinker ChemistryOrganic SynthesisOrganometallic SynthesisPeptide ChemistryStructure-activity Relationship AnalysisBioactivityBioactivity AssessmentMedicinal Chemistry ApplicationsOrganometallic ComplexesPeptide Mass SpectrometryProtease InhibitorsUrea LinkersUrease Inhibitors
ABSTRACT Fourteen new ferrocene derivatives containing urea linker were synthesized from the reaction of ferrocenecarbonyl azide with aromatic amines. The structures of the synthetic compounds were confirmed by 1 H NMR, 13 C NMR, IR, mass spectrometry and elemental analysis. These organometallic compounds were evaluated by in vitro protease assay using fluorogenic substrate peptide, and several showed potent inhibition against HIV‐1 protease. Copyright © 2012 John Wiley & Sons, Ltd.
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On the medicinal chemistry of ferrocene
M.F.R. Fouda, Mokhles M. Abd‐Elzaher, Rafeek A. Abdelsamaia et al. · Applied Organometallic Chemistry · 2007 · 458 citations
Sushil K. Kashaw, Varsha Kashaw, Pradeep Mishra et al. · European Journal of Medicinal Chemistry · 2009 · 145 citations