M1 Macrophages Activate Notch Signalling in Epithelial Cells: Relevance in Crohn’s Disease

Abstract

M1, but not M2, macrophages are associated with HIF-1-dependent induction of Notch ligands and activation of epithelial Notch signalling pathway. In the mucosa of chronic CD patients, the prevalence of M2 macrophages is associated with diminution of Notch signalling and impaired enterocyte differentiation.