GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells. - Concepedia

Concepedia

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GSKJ4, A Selective Jumonji H3K27 Demethylase Inhibitor, Effectively Targets Ovarian Cancer Stem Cells.

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References

2015

Year

Hirotsugu Sakaki, Masashi Okada, Kenta Kuramoto, Hiroyuki Takeda, Hikaru Watarai, Shuhei Suzuki, Shizuka Seino, Manabu Seino, Tsuyoshi Ohta, Satoru Nagase,

Abstract

Our findings suggest that H3K27 methylation may have an inhibitory role in the maintenance of CSCs and that GSKJ4 may represent a novel class of CSC-targeting agents.