PubMed · 2016 · 104 citations · 33 references
MedicineDermatologyOphthalmologyAllergyCosmetic DermatologyDermatopathologyAtopic DermatitisEyelid EdemaHyperpigmentation TreatmentMelasma ManagementOcular Surface DiseasePigmentary DisordersAzelaic Acid TherapyChemical Peels For MelasmaLaser Therapy For MelasmaPeriorbital EdemaPeriorbital Hyperpigmentation TreatmentPigmentationSkin HyperpigmentationTopical Depigmenting Therapy
Periorbital hyperpigmentation is a commonly encountered condition. There is very little scientific data available on the clinical profile and pathogenesis of periorbital hyperpigmentation. Periorbital hyperpigmentation is caused by various exogenous and endogenous factors. The causative factors include genetic or heredity, excessive pigmentation, postinflammatory hyperpigmentation secondary to atopic and allergic contact dermatitis, periorbital edema, excessive vascularity, shadowing due to skin laxity and tear trough associated with aging. There are a number of treatment options available for periorbital hyperpigmentation. Among the available alternatives to treat dark circles are topical depigmenting agents, such as hydroquinone, kojic acid, azelaic acid, and topical retinoic acid, and physical therapies, such as chemical peels, surgical corrections, and laser therapy, most of which are tried scientifically for melasma, another common condition of hyperpigmentation that occurs on the face. The aim of treatment should be to identify and treat the primary cause of hyperpigmentation as well as its contributing factors.
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A New Formula for Depigmenting Human Skin
Albert M. Kligman · Archives of Dermatology · 1975 · 428 citations
Acquired, bilateral nevus of Ota-like macules
Yoshiaki Hori, Makoto Kawashima, Kuniaki Oohara et al. · Journal of the American Academy of Dermatology · 1984 · 208 citations
Medicine, Dermatology, Pathology +9