Discovery of new low-molecular-weight p53–Mdmx disruptors and their anti-cancer activities

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.6K citations

Tumor Biology, Small-molecule Antagonists, Mdm2-p53 Interaction +14

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

Qingjie Ding, Zhuming Zhang, Jinjun Liu et al. · Journal of Medicinal Chemistry · 2013 · 583 citations · Full text

Drug Target, Chemical Biology, Cancer Biology +19

Design, Synthesis, and Evaluation of Novel Boronic-Chalcone Derivatives as Antitumor Agents

Srinivas K. Kumar, Erin R. Hager, Catherine Pettit et al. · Journal of Medicinal Chemistry · 2003 · 301 citations

Normal Breast Cells, Pharmacotherapy, Chemistry +20

Cytoplasmic destruction of p53 by the endoplasmic reticulum‐resident ubiquitin ligase ‘Synoviolin’

Satoshi Yamasaki, Naoko Yagishita, Takeshi Sasaki et al. · The EMBO Journal · 2006 · 279 citations · Full text

MDMX Overexpression Prevents p53 Activation by the MDM2 Inhibitor Nutlin

Baoli Hu, Daniele M. Gilkes, Bilal Farooqi et al. · Journal of Biological Chemistry · 2006 · 234 citations · Full text

Tumor Biology, Radiation Oncology, Mdmx Sirna +13