Scientific Reports · 2016 · 51 citations · 47 references
Public HealthMaternal HealthToxicologyHeavy Metal ToxicologyHigh-risk PregnancyInfant HealthEnvironmental Heavy Metal ExposureIntrauterine Growth RestrictionPerinatal Risk FactorsPregnancyPrenatal Risk AssessmentPrenatal ToxicologyBiomarkers Of Cadmium ExposureCadmium Risk AssessmentEnvironmental Exposures During PregnancyExposure Odds RatioFetal Growth Restriction Risk AssessmentGraphite Furnace Atomic Absorption SpectrometryGraphite Furnace Atomic Absorption SpectroscopyPrenatal Heavy Metal Exposure
The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite furnace atomic absorption spectrometry. The rate and odds ratio (OR) for SGA infant were calculated. The rate for SGA infant was 10.6% among subjects with H-Cd (≥1.06 μg/L), significantly higher than 7.5% among subjects with L-Cd (<1.06 μg/L). OR was 1.45 (95% CI: 1.11, 1.90; P = 0.007) among subjects with H-Cd. Adjusted OR for SGA infants was 1.43 (95% CI: 1.09, 1.88; P = 0.007) among subjects with H-Cd. Taken together, we observe the fact that maternal Cd exposure at middle gestational stage, elevates the risk of SGA in contrast to early gestational stage. The present results might be interesting and worth more discussing, and guarantee to further studies.
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A global reference for fetal-weight and birthweight percentiles
Rafael Mikolajczyk, Jun Zhang, Ana Pilar Betrán et al. · The Lancet · 2011 · 477 citations
Medicine, Obstetrics, Pediatrics +14