An origami-inspired ultrastretchable bioprobe film device

Abstract

We have developed an ~1,000% stretchable and flexible bioprobe film device, which enables to follow the shape of a spherical and deformable biological tissue while the electrical signals are recorded (Fig. 1). As the film material, we use a highly-biocompatible parylene film, which shows the high stretchability by embedding slit patterns in the film, so call `Amanogawa' design in traditional `Origami (or Kirigami)'. The fabricated 10-μm-thick parylene film exhibits the stretchability of 1,100%. In addition, the parylene film-based bioprobe device is fabricated for in vivo electrocardiogram (ECoG) recordings of a mouse brain. We demonstrate the simultaneous ECoG recordings from both the visual and sensory cortices by stretching the film and changing the electrode gap, indicating that the recording capability of the electrodes while the film stretches.