Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment

Abstract

Low intensity irradiation with 635 ± 5 nm diode laser inhibited TGF-β1/Smad3-mediated fibroblast-myofibroblast transition and this effect involved the modulation of TRPC1 ion channels. These data contribute to support the potential anti-fibrotic effect of LLLT and may offer further informations for considering this therapy as a promising therapeutic tool for the treatment of tissue fibrosis.