Ophthalmic surgery, lasers & imaging retina · 1991 · 17 citations · 15 references
MedicineOphthalmologyPharmacologyOcular Drug DeliveryOcular PharmacologyPharmacodynamicsDiabetes MellitusDiabetes PharmacotherapyDiabetic RetinopathyOcular BarriersOcular PharmacodynamicsRetinal PharmacotherapyBlood - Retinal BarrierBlood-retina Barrier PenetrationBlood-retinal Barrier DisruptionBlood-retinal Barrier DysfunctionBlood-retinal Barrier PermeabilityDiabetic Retinopathy Barrier BreakdownOuter Blood-retinal BarrierRetinal Pharmacology
The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.
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Aminoguanidine Prevents Diabetes-Induced Arterial Wall Protein Cross-Linking
M. Brownlee, Helen Vlassara, A. Kooney et al. · Science · 1986 · 1.1K citations
Collagen Aging In Vitro by Nonenzymatic Glycosylation and Browning
Robert R. Kohn, Anthony Cerami, Vincent M. Monnier · Diabetes · 1984 · 174 citations
Life Sciences, Biochemistry, Aging +12