Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer.

Abstract

These findings reflect the different biologic characteristics of the lesions in a heterogeneous tumor such as prostate cancer and suggest that a time-dependent metabolic cascade may occur in advanced prostate cancer, with initial uptake of 11C-methionine in dormant sites followed by increased uptake of 18F-FDG during progression of disease.