<i>Helicobacter pylori</i> Activates IL‐6‐STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

Abstract

H. pylori-induced STAT3 activation is mediated, at least in part, through ROS-induced upregulation of IL-6 expression. These findings provide a novel molecular mechanism responsible for H. pylori-induced gastritis and gastric carcinogenesis.