Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia

Reversible middle cerebral artery occlusion without craniectomy in rats.

Enrique Zea Longa, Philip R. Weinstein, Shaun W. Carlson et al. · Stroke · 1989 · 7.4K citations · Full text

Mca Occlusion, Cerebral Vascular Regulation, Neurovascular Disease +18

Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia

Ji Hoe Heo, Jacinta Lucero, Takeo Abumiya et al. · Journal of Cerebral Blood Flow & Metabolism · 1999 · 550 citations

Basal Lamina, Cerebrovascular Disease, Cerebral Vascular Regulation +17

Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation

H.-S.V Chen, Y.F Wang, Paul Edgecomb et al. · Neuroscience · 1998 · 199 citations

Neurophysiology, Medicine, Neurotransmitter +12

Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95

Sergio Gascón, Mónica Sobrado, J.M. Roda et al. · Molecular Psychiatry · 2007 · 128 citations

Protein Psd-95, Biochemistry, Neurophysiology +13

Memantine Enhances Recovery From Stroke

Héctor E. López‐Valdés, Andrew N. Clarkson, Yan Ao et al. · Stroke · 2014 · 120 citations · Full text