Synthesis of 2,3‐Disubstituted Quinazolinone Derivatives through Copper Catalyzed C–H Amidation Reactions

Abstract

Abstract The synthesis of quinazolinone derivatives was achieved from 2‐iodobenzamide derivatives and various benzylamines, allylamine, and cinnamylamine derivatives through a one‐pot copper‐catalyzed reaction. In this reaction, the amine component (benzylamine/allylamine/cinnamylamine) is N ‐arylated with 2‐iodobenzamide derivatives through Ullman coupling, followed by an intramolecular C–H amidation in the presence of copper catalyst.