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<italic>Brief Communication:</italic> Matrical Inclusions Induced by Clofibrate in Hepatic Microbodies of Rats Fed 2-Acetylaminofluorene<xref ref-type="fn" rid="fn2">2</xref>
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1975
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PathologyHyperplastic StateMatrical Inclusions InducedHepatobiliary TumorToxicologyHepatotoxicityHepatology FibrosisHealth SciencesBiochemistryLiver PhysiologyHistopathologyHepatic MicrobodiesRats FedCell BiologyHepatologyHyperplastic Liver NodulesPhysiologyHepatitisAbnormal InclusionsLiver DiseaseLiver CancerLiverMedicineHepatocellular Carcinoma
Abnormal inclusions in microbodies were induced by clofibrate in hepatocytes of hyperplastic liver nodules in rats fed 2-acetylaminofluorene. These were matrical tubules and plates, each with the same ultrastructural features as those reported previously by other investigators. A hyperplastic state of hepatocytes induced by hepatocarcinogens might be related to the formation of these inclusions in response to clofibrate.