Improved immunogenicity and protective efficacy of a divalent DNA vaccine encoding Brucella L7/L12-truncated Omp31 fusion protein by a DNA priming and protein boosting regimen

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants

Mark Roman, Elena Martín‐Orozco, Justin S. Goodman et al. · Nature Medicine · 1997 · 916 citations

Life Sciences, Immunology, Molecular Biology +14

Immunization of mice with recombinant L7L12 ribosomal protein confers protection against Brucella abortus infection

Sérgio C. Oliveira, Gary A. Splitter · Vaccine · 1996 · 181 citations

Life Sciences, Immunology, Infectious Diseases +12

Progress in Brucella vaccine development

Xinghong Yang, Jerod A. Skyberg, Ling Cao et al. · Frontiers in Biology · 2012 · 128 citations · Full text

Veterinary Medicine, Infectious Diseases, Veterinary Microbiology +12

Protection of BALB/c Mice against<i>Brucella abortus</i>544 Challenge by Vaccination with Bacterioferritin or P39 Recombinant Proteins with CpG Oligodeoxynucleotides as Adjuvant

Ayman Al-Mariri, Anne Tibor, Pascal Mertens et al. · Infection and Immunity · 2001 · 126 citations

Veterinary Medicine, Immunology, Infectious Diseases +17