Journal of Immunology Research · 2016 · 35 citations · 23 references
Life SciencesMicrobiologyMolecular BiologyEpigeneticsEpigenomicsMicrobiome ResearchColorectal CancerDevelopmental EpigenomicsGut MicrobiomeGut MicrobiotaInflammatory Bowel DiseaseMicrobiome DevelopmentAge-associated Dna Methylation ChangesColorectal Cancer PredispositionDevelopmental Origins Of DiseaseEarly-life Gut MicrobiomeEarly-onset Colorectal CancerGut Microbiome AlterationsPediatric Ulcerative ColitisPostnatal Microbiome Development
Epigenetic and microbiome changes during pediatric development have been implicated as important elements in the developmental origins of inflammatory bowel diseases (IBDs) including Crohn's disease (CD) and ulcerative colitis (UC), which are linked to early onset colorectal cancer (CRC). Colonic mucosal samples from 22 control children between 3.5 and 17.5 years of age were studied by Infinium HumanMethylation450 BeadChips and, in 10 cases, by 454 pyrosequencing of the bacterial 16S rRNA gene. Intercalating age-specific DNA methylation and microbiome changes were identified, which may have significant translational relevance in the developmental origins of IBD and CRC.
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Epidemiology and Natural History of Inflammatory Bowel Diseases
Jacques Cosnes, Corinne Gower‐Rousseau, Philippe Seksik et al. · Gastroenterology · 2011 · 2.2K citations · Full text
Medicine, Immunology, Pathology +14