Concepedia

Expression and Prognostic Significance of Metalloproteinases and Their Tissue Inhibitors in Patients With Small-Cell Lung Cancer

M. Michael, Bojana Babic, Rama Khokha, Ming‐Sound Tsao, Jcm Ho, Melania Pintilie, Kevin J. Leco, Dean Chamberlain, Frances A. Shepherd

Journal of Clinical Oncology · 1999 · 160 citations · 28 references

DOI

Abstract

MMPs and TIMPs are widely expressed in SCLC. Increased tumoral expression of MMP-3, -11, and -14 were independent negative prognostic factors for survival. The results support the evaluation of synthetic MMP inhibitors in patients with SCLC.

References

28

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Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma

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Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP‐2 in lung carcinomas correlates with the expression of membrane‐type matrix metalloproteinase (MT‐MMP) and with lymph node metastasis

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Tumor-associated angiogenesis: mechanisms, clinical implications, and therapeutic strategies.

James M. Pluda · PubMed · 1997 · 243 citations