Concepedia

Publication | Open Access

DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection

DOIFull Paper Access

34

Citations

31

References

2015

Year

Maria Antonella Burza, Benedetta Maria Motta, Rosellina Margherita Mancina, Piero Pingitore, Carlo Pirazzi, Saverio Massimo Lepore, Rocco Spagnuolo, Patrizia Doldo, Cristina Russo, Verónica Lazzaro,
Hepatology

Abstract

DEPDC5 variants increase fibrosis progression in European subjects with chronic HCV infection. Our findings suggest that DEPDC5 down-regulation may contribute to HCV-related fibrosis by increasing MMP2 synthesis through the β-catenin pathway.

References

YearCitations

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