Concepedia

Publication | Closed Access

Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.

355

Citations

0

References

2007

Year

Yoshihiko Hoshida, Jing Xian Xu, Shigeki Fujita, Itsuko Nakamichi, Jun Ikeda, Y. Tomita, S. Nakatsuka, J.-i. Tamaru, Atsushi Iizuka, Tsutomu Takeuchi,
PubMed

Abstract

The majority of cases of RA-LPD show similar clinicopathological characteristics irrespective of MTX medication, except for spontaneous regression of LPD after withdrawal of MTX in MTX-LPD, and a shorter interval between the diagnosis of RA and LPD in MTX-LPD than in non-MTX-LPD. RA-LPD cases showed younger age of onset, female predominance, unfavorable prognosis, and higher frequencies of DLBCL and EBV positivity compared to sporadic LPD.