Exome Array Analysis Identifies a Common Variant in <i>IL27</i> Associated with Chronic Obstructive Pulmonary Disease

Abstract

In an exome array analysis of COPD, we identified nonsynonymous variants at previously described loci and a novel exome-wide significant variant in IL27. This variant is at a locus previously described in genome-wide associations with diabetes, inflammatory bowel disease, and obesity and appears to affect genes potentially related to COPD pathogenesis.