A bioluminescent sensor for highly selective and sensitive detection of human carboxylesterase 1 in complex biological samples

Abstract

A highly selective and sensitive bioluminescent sensor (DME) for human carboxylesterase 1 (hCE1) has been developed and well characterized. DME could be used for real-time monitoring of hCE1 activities in complex biological samples and for bio-imaging of endogenous hCE1 in living cells.