Whole Body Autoradiographic Studies of the Distribution of Sulphur 35-Labelled Mustard Gas in Mice

Abstract

Mustard gas labeled with S/sup 35/ was applied to the skin of mice and also given by intravenous injection. The distribution of the radioactivity was followed by whole-body autoradiography. A high uptake was found in the kidneys and liver; the nasal region rapidly accumulated a high activity, and considerable activity was also evident in the central nervous system. Some experiments in pregnant animals demonstrated a passage of radioactivity to the fetuses.