In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

Ann K. Daly, Peter T. Donaldson, Pallav Bhatnagar et al. · Nature Genetics · 2009 · 1K citations

Life Sciences, Genetics, Pharmacology +14

Liver transplantation for acute liver failure from drug induced liver injury in the United States

Mark W. Russo, Joseph A. Galanko, Roshan Shrestha et al. · Liver Transplantation · 2004 · 483 citations

Medicine, Pharmacology, Clinical Pharmacology +6

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

Jaana Laine, Seppo Auriola, Markku Pasanen et al. · Xenobiotica · 2009 · 256 citations

Medicine, Pharmacology, Toxicology +17

Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes.

Judy D. Easterbrook, C. Lu, Y Sakai et al. · PubMed · 2001 · 192 citations

Medicine, Biochemistry, Pharmacology +16

Triethylenethiophosphoramide Is a Specific Inhibitor of Cytochrome P450 2B6: Implications for Cyclophosphamide Metabolism

James M. Rae, Nadia Soukhova, David A. Flockhart et al. · Drug Metabolism and Disposition · 2002 · 113 citations

Medicine, Biochemistry, Pharmacology +17