Concepedia

Synthesis, antibacterial and anti-MRSA activity, in vivo toxicity and a structure–activity relationship study of a quinoline thiourea

Niamh Dolan, Declan P. Gavin, Ahmed Eshwika, Kevin Kavanagh, John McGinley, John C. Stephens

Bioorganic & Medicinal Chemistry Letters · 2015 · 47 citations · 25 references

Concepts

PharmacyMedicinal ChemistryPharmacologyDrug DiscoveryStructure-activity RelationshipsSynthetic Medicinal ChemistryAntibacterial AgentsAntibacterial PharmacologyAntibacterial PharmacotherapyAntibacterial TherapyAntimicrobial PharmacodynamicsAntimicrobial ToxicityAntibacterial ToxicityQuinoline ChemistryQuinoline SynthesisStructure - Activity Relationship MappingStructure - Activity Relationship OptimizationStructure-activity Relationship Modeling

References

25

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +16

Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts

Tomotaka Okino, Yasutaka Hoashi, Yoshiji Takemoto · Journal of the American Chemical Society · 2003 · 1.4K citations

Natural Sciences, Chemistry, Catalysis +4

Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.

John R. W. Govan, Vojo Deretić · Microbiological Reviews · 1996 · 692 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +11

Introduction to Medicinal Chemistry

Arthur Shepherd · Biochemical Education · 1976 · 490 citations

Pharmacy, Chemistry, Medicinal Chemistry +12

Steric effects. I. Esterification and acid-catalyzed hydrolysis of esters

Marvin Charton · Journal of the American Chemical Society · 1975 · 488 citations

Natural Sciences, Chemistry, Catalysis +10