CD8 ⁺ T Cells Regulate Monopoiesis and Circulating Ly6C ^high Monocyte Levels in Atherosclerosis in Mice

Abstract

These data suggest that CD8(+) T cells promote atherosclerosis by controlling monopoiesis and circulating monocyte levels, which ultimately contributes to plaque macrophage burden without affecting direct monocyte recruitment, identifying this cell subset as a critical regulator of proatherogenic innate immune cell responses in atherosclerosis.