Construction of pyrazolo[5,1-a]isoindol-8(3aH)-one derivatives via phosphine-catalyzed cyclization of electron-deficient alkynes and N-amino substituted phthalimide

Abstract

A novel method for the synthesis of diversely functionalized pyrazolo[5,1-<italic>a</italic>]isoindol-8(3<italic>aH</italic>)-ones is developed <italic>via</italic> phosphine-catalyzed reaction of electron-deficient alkynes and <italic>N</italic>-amino substituted phthalimide.