Concepedia

Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly Activated by Cyclic AMP 1/Ras-Related Protein 1 Axis

Morihiko Aoyama, Haruya Kawase, Akio Monji, Toyoaki Murohara

Circulation Heart Failure · 2016 · 42 citations · 30 references

DOI

Abstract

DPP4i restores cardiac remodeling and apoptosis caused by the pathological decline in circulating GLP-1 in response to pressure overload. EPAC1 is essential for cardiomyocyte survival via the cAMP/Rap1 activation independently of PKA.

References

30

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Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

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