Towards a cell-based mechanostat theory of bone: the need to account for osteocyte desensitisation and osteocyte replacement

Bone “mass” and the “mechanostat”: A proposal

Harold M. Frost · The Anatomical Record · 1987 · 2.1K citations

Natural Sciences, Biophysics, Biomechanics +16

Effects of mechanical forces on maintenance and adaptation of form in trabecular bone

R. Huiskes, R Ronald Ruimerman, Harry van Lenthe · Nature · 2000 · 1.2K citations

Natural Sciences, Biophysics, Orthopedic Surgery +14

Mechanotransduction in bone—role of the lacunocanalicular network

Elisabeth H. Burger, Jenneke Klein‐Nulend · The FASEB Journal · 1999 · 890 citations

Natural Sciences, Bioengineering, Physiology +17

Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts

Laurence Vico, Philippe Collet, Alain Guignandon et al. · The Lancet · 2000 · 810 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +14

The behavior of adaptive bone-remodeling simulation models

Harrie Weinans, R. Huiskes, H.J. Grootenboer · Journal of Biomechanics · 1992 · 624 citations · Full text

Medicine, Bioengineering, Orthopedic Surgery +12