Concepedia

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

Kenta Mizoi, Masato Takahashi, Masami Haba, Masakiyo Hosokawa

Bioorganic & Medicinal Chemistry Letters · 2015 · 17 citations · 18 references

DOI

Concepts

References

18

The discovery and development of HMG-CoA reductase inhibitors.

Akira Endo · Journal of Lipid Research · 1992 · 840 citations · Full text

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Notes- A Convenient Synthesis of Water-Soluble Carbodiimides.

John C. Sheehan, Philip A. Cruickshank, Gregory Boshart · The Journal of Organic Chemistry · 1961 · 423 citations

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Characterization of CPT-11 hydrolysis by human liver carboxylesterase isoforms hCE-1 and hCE-2.

Rod Humerickhouse, K Lohrbach, Lin Li et al. · PubMed · 2000 · 356 citations

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Metabolism of cocaine and heroin is catalyzed by the same human liver carboxylesterases.

Lisa M. Kamendulis, Monica R. Brzezinski, Evgenia V. Pindel et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 191 citations

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Metabolic Activation of CPT-11, 7-Ethyl-10-(4-(1-piperidino)-1-piperidino)carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase.

Masakiyo Hosokawa, Ryo Atsumi, Wataru Suzuki et al. · Biological and Pharmaceutical Bulletin · 1994 · 175 citations · Full text

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