Concepedia

The discovery and development of HMG-CoA reductase inhibitors.

Akira Endo

Journal of Lipid Research · 1992 · 840 citations · 98 references

DOIFull text

Open access

Concepts

Abstract

During the 1950s and 1960s, many cholesterol-lowering agents were reported and introduced into clinical use, in-

References

98

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

Greg Brown, John J. Albers, Lloyd D. Fisher et al. · New England Journal of Medicine · 1990 · 2.2K citations · Full text

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All ras proteins are polyisoprenylated but only some are palmitoylated

John F. Hancock, Anthony I. Magee, Julie E. Childs et al. · Cell · 1989 · 1.8K citations

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Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alfred W. Alberts, J Chen, G. W. Kuron et al. · Proceedings of the National Academy of Sciences · 1980 · 1.6K citations · Full text

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Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.

Annals of Internal Medicine · 1980 · 1.4K citations

, , +14

Receptor-Mediated Control of Cholesterol Metabolism

Michael S. Brown, Joseph L. Goldstein · Science · 1976 · 963 citations

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