The multicopy appearance of a large inverted duplication and the sequence at the inversion joint suggest a new model for gene amplification.

DNA sequencing with chain-terminating inhibitors

Frederick Sanger, S. Nicklen, Alan Coulson · Proceedings of the National Academy of Sciences · 1977 · 69.3K citations · Full text

Life Sciences, Microbiology, Molecular Biology +10

Optimal computer folding of large RNA sequences using thermodynamics and auxiliary information

Michael Zuker, Patrick Stiegler · Nucleic Acids Research · 1981 · 3.6K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Geoffrey M. Wahl, Michael Stern, George R. Stark · Proceedings of the National Academy of Sciences · 1979 · 3.4K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Amplification of an Esterase Gene Is Responsible for Insecticide Resistance in a California <i>Culex</i> Mosquito

Claude Mouchès, Nicole Pasteur, Jean Baptiste Bergé et al. · Science · 1986 · 347 citations

Life Sciences, Entomology, Genetics +15

Amplification of genes for chorion proteins during oogenesis in <i>Drosophila melanogaster</i>

Allan C. Spradling, Anthony P. Mahowald · Proceedings of the National Academy of Sciences · 1980 · 304 citations · Full text

Life Sciences, Biology, Genetics +16