G protein‐coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57<scp>BL</scp>/6 female mice

Abstract

We suggest that activation of GPER exerts an inhibitory effect on colonic motility by promoting NO release from myenteric nitrergic nerves. These results raise a possibility that GPER may be involved in mediating the inhibitory effect of estrogen on colonic motor functions, via a non-genomic, neurogenic mechanism.