Concepedia

Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma, Masanori Hatakeyama

Biochemical and Biophysical Research Communications · 2015 · 21 citations · 24 references

DOI

Concepts

References

24

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

Marco Tartaglia, Ernest L. Mehler, Rosalie Goldberg et al. · Nature Genetics · 2001 · 1.7K citations

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Diversity and Functional Consequences of Germline and Somatic PTPN11 Mutations in Human Disease

Marco Tartaglia, Simone Martinelli, Lorenzo Stella et al. · The American Journal of Human Genetics · 2006 · 431 citations · Full text

, , +16

PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects

Maria Kontaridis, Kenneth D. Swanson, Frank David et al. · Journal of Biological Chemistry · 2005 · 332 citations · Full text

, , +17

Parafibromin/Hyrax Activates Wnt/Wg Target Gene Transcription by Direct Association with β-catenin/Armadillo

Christian Mosimann, George Hausmann, Konrad Basler · Cell · 2006 · 310 citations · Full text

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Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

Si Qing Zhang, William G. Tsiaras, Toshiyuki Araki et al. · Molecular and Cellular Biology · 2002 · 279 citations · Full text

, , +17