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Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats

Friederike Behmenburg, Marianne Dorsch, Ragnar Huhn, David Mally, André Heinen, Markus W. Hollmann, Marc Moritz Berger

PLoS ONE · 2015 · 45 citations · 33 references

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Abstract

This study shows that in male rats protein kinase G-dependent opening of mBKCa channels plays a pivotal role in sildenafil-induced cardioprotection.

References

33

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K<sub>ATP</sub>channels in rabbits

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Fadi N. Salloum, Chang Yin, Lei Xi et al. · Circulation Research · 2003 · 240 citations · Full text