The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

Sarah R. Wilson, Lydia Thé, Lyn Batia, +6

Cell

InflammationAutoimmune DiseaseAtopic DermatitisMedicineImmunology +8

Abnormal osmotic regulation in <i> trpv4 ^-/- </i> mice

Wolfgang Liedtke, Jeffrey M. Friedman

Proceedings of the National Academy of Sciences

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

Ferda Cevikbas, Xidao Wang, Tasuku Akiyama, +15

Journal of Allergy and Clinical Immunology

Signal TransductionMolecular PhysiologyAdaptive Immune SystemMedicineImmunology +10

Proteinase-Activated Receptor-2 Mediates Itch: A Novel Pathway for Pruritus in Human Skin

Martin Steinhoff, Ulrich Neisius, Akihiko Ikoma, +4

Journal of Neuroscience

Neuronal Proteinase-activated Receptor-2Allergy MedicineNovel PathwayImmunologySkin Allergy +14

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

Sarah R. Wilson, Kristin A. Gerhold, Amber Bifolck-Fisher, +4

Nature Neuroscience

Molecular PharmacologyMolecular PhysiologyAllergySignal TransductionBiochemistry +6

A subpopulation of nociceptors specifically linked to itch

Liang Han, Chao Ma, Qin Liu, +14

Nature Neuroscience

AllergyHealth SciencesNeuroanatomyPain MedicineNeuropathic Pain +7

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

Noritaka Imamachi, Goon Ho Park, Hyosang Lee, +4

Proceedings of the National Academy of Sciences

Multiple MechanismsSynaptic TransmissionNeurotransmitterSignal RecognitionMolecular Biology +25

Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis

Wouter Everaerts, Xiao-guang Zhen, Debapriya Ghosh, +15

Proceedings of the National Academy of Sciences

Protease‐activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Andrew Grant, Graeme S. Cottrell, Silvia Amadesi, +15

The Journal of Physiology

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

Carlene Moore, Ferda Cevikbas, H. Amalia Pasolli, +11

Proceedings of the National Academy of Sciences

DermatologyCellular PhysiologyInflammationSkin PharmacologyEpidermal Trpv4 +15