Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752

Cancer statistics, 2014

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Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

Shannon M. McAuliffe, Stefanie L. Morgan, Gregory A. Wyant et al. · Proceedings of the National Academy of Sciences · 2012 · 327 citations · Full text

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Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

Ian E. Krop, Tim Demuth, Tina Guthrie et al. · Journal of Clinical Oncology · 2012 · 317 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +16

<i>Notch3</i> Gene Amplification in Ovarian Cancer

Joon T. Park, Mei Li, Kentaro Nakayama et al. · Cancer Research · 2006 · 261 citations

Medicine, Genetics, Oncology +17

Notch3 Overexpression Is Related to the Recurrence of Ovarian Cancer and Confers Resistance to Carboplatin

Joon Tae Park, Xu Chen, Claes G. Tropé et al. · American Journal Of Pathology · 2010 · 186 citations · Full text

Medicine, Molecular Biology, Oncology +12