Blockade of cannabinoid 1 receptor improves GLP-1R mediated insulin secretion in mice

Leptin-regulated endocannabinoids are involved in maintaining food intake

Vincenzo Di Marzo, Sravan K. Goparaju, Lei Wang et al. · Nature · 2001 · 1.6K citations

Obesity, Nutrition, Cannabis Use +7

Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

Luc F. Van Gaal, Aila Rissanen, André Scheen et al. · The Lancet · 2005 · 1.5K citations · Full text

Obesity, Metabolic Syndrome, Cannabis Use +10

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Daniela Cota, Giovanni Marsicano, Matthias H. Tschöp et al. · Journal of Clinical Investigation · 2003 · 1.1K citations · Full text

Peripheral Lipogenesis, Energy Balance, Food Intake +21

Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice

Andreas Zimmer, Anne Zimmer, Andrea G. Hohmann et al. · Proceedings of the National Academy of Sciences · 1999 · 1.1K citations · Full text

Cb1 Gene, Experimental Pharmacology, Cannabinoid Pharmacology +16

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity

Douglas Osei‐Hyiaman, Michael A. DePetrillo, Pál Pacher et al. · Journal of Clinical Investigation · 2005 · 982 citations · Full text

Fatty Liver Disease, Obesity, Metabolic Syndrome +18