Synthesis of optically pure (S)-2-amino-5-arylpent-4-ynoic acids by Sonogashira reactions and their potential use as highly selective potent inhibitors of aldose reductase

Abstract

A new and convenient synthesis of optically pure (<italic>S</italic>)-2-amino-5-[aryl]pent-4-ynoic acids (alkynylated amino acids) is reported.